Through a patented and proprietary process , APIC A2M is isolated and concentrated from your blood to biologically clean out your joint or disc space and provide a healthy enviroment for repair.


For the majority of patients with pain, their arthritic joint or disc space houses more destructive enzymes than the body can handle. While the APIC A2M Molecule is our body’s own defense mechanism, it is unable to enter the joint or disc space in large enough quantities due to its large size and complex structure. As a result, it is necessary to inject additional isolated concentrated APIC A2M into the affected area to restore balance and pain relief.

An injection of isolated concentrated APIC A2M, derived from your own blood and placed directly into your joint or disc space, can provide the necessary amount of APIC A2M to bind and remove these destructive proteases.

What does APIC A2M have to do with solving my joint or back pain?

APIC Alpha-2-Macroglobulin (A2M) therapy is different from other treatments. APIC A2M is a naturally occurring molecule found in your blood, which when administered in highly concentrated doses, acts as a powerful protector against cartilage breakdown. APIC A2M eliminates inflammation, attaches to, and removes the destructive enzymes and proteases, which damage cartilage cells and tissues within the joint or disc space.

Early Treatment Equals Better Recovery

For patients suffering from joint or back pain, APIC A2M therapy is an exciting advancement in orthopedic science resulting from years of research. Early treatments of this miracle molecule delay the need for more aggressive and costly procedures, including surgery. Your current treatment may only be managing the symptoms of your joint or back pain — not addressing the root cause. Though most patients find these types of treatments offer temporary relief they are not focusing on the underlying source of arthritic joint and back pain.

Breakthrough therapy indicator

Research has identified the “pain protein” Fibronectin-Aggrecan Complex (FAC) as a link with painful inflammation and cartilage breakdown. Your doctor can test your synovial fluid for the presence of FAC and determine if you are an appropriate candidate for APIC A2M Therapy.

To learn more, read these articles about APIC A2M

Cytokine evaluation in individuals

The pathophysiology underlying degenerative disc disease and its implication in painful syndromes remain unclear. However, spine magnetic resonance imaging (MRI)

Does the presence of the fibronectin-aggrecan

Protein biomarkers associated with lumbar disc disease have been studied as diagnostic indicators and therapeutic targets. Recently, a cartilage degradation product,

Outcome of Lumbar Epidural Steroid Injection

A single-center, prospective, consecutive case series of patients undergoing epidural lavage before the treatment of radiculopathy due to lumbar disc herniation.

Are Persistently Symptomatic Vertebral Compression

A case-control study with prospectively collected samples for laboratory analysis in a series of patients with spinal fragility fractures and a series of patients without fracture

Is the Fibronectin-Aggrecan Complex

To investigate the presence of inflammatory cytokines and the fibronectinaggrecan complex (FAC) in persons undergoing surgical treatment for cervical radiculopathy

Does a Fibronectin and Aggrecan Complex

To determine the presence of a fibronectin-aggrecan complex (FAC) in the disk space of persons with chronic low back pain as relates to provocative diskography.

A critical evaluation of discography

The study is a prospective observational study of 48 continuous patients with symptomatic lumbar degenerative disk disease. Each patient underwent discography, MRI,

Biologic Augmentation of Rotator

Clinical studies have demonstrated a high rate of incomplete healing of rotator cuff tendon repair. Since healing of such a repair is dependent on bone ingrowth into the repaired tendon


An important component of tissue engineering (TE) is the supporting matrix upon which cells and tissues grow, also known as the scaffold. Scaffolds must easily integrate with host tissue

Sutureless Fixation of Amniotic Membrane

1 Department of Ophthalmology, Klinikum Chemnitz gGmbH, Chemnitz, Germany, 2 Institute of Anatomy, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany,

Adipose stem cells for intervertebral disc regeneration

New regenerative treatment strategies are being developed for intervertebral disc degeneration of which the implantation of various cell types is promising.

Applications of Amniotic Membrane

The amniotic membrane (AM) and amniotic fluid (AF) have a long history of use in surgical and prenatal diagnostic applications, respectively. In addition

Amniotic membrane used to repair human articular cartilage

The authors cultivated the chondrocytes (cells that form part of the cartilaginous tissue), isolated from human articular cartilage, on the amniotic membrane over a period

Correlation of Intra-Articular Ankle Pathology

Articular cartilage degeneration is mediated by inflammatory cytokines and fragments of structural matrix proteins. Few studies have examined the role of these biomarkers

Finding the Replacement for HA Injections

Jeff White is the founder and principal of Medtech Advisory Group LLC and former global director of Business Development and Licensing, Synthes Spine.

Fibronectin-Aggrecan Complex Test

FACT™ measures the presence of the Fibronectin-Aggrecan Complex (FAC) in a fluid specimen taken from patients with spine related pain

Platelet-Rich Plasma Increases

The effect of platelet-rich plasma on chondrocytes has been studied in cell and tissue culture. Less attention has been given to the effect of platelet-rich plasma

Identification of a Novel Fibronectin-Aggrecan

Molecular biomarkers associated with knee pain may be useful as diagnostic modalities, prognostic indicators, and surrogate end points for therapeutic trials.

Diagnostic Utility of Cytokine Biomarkers

The diagnosis of clinically important meniscal tears of the knee remains challenging, and it is unknown why only some injuries become painful. The role of inflammatory cytokines in

Fibronectin Aggrecan Complex Test (FACT™)

The Fibronectin Aggrecan Complex Test (FACT™) is an enzyme linked immunosorbent sandwich assay (ELISA) that measures the presence of a Fibronectin-Aggrecan Complex (FAC).

Identification of Alpha 2 Macroglobulin

Identification of Alpha 2 Macroglobulin (A2M) as a master inhibitor of cartilage degrading factors that attenuates posttraumatic osteoarthritis progression.

Identification of A2 -Macroglobulin

Identification of A2-Macroglobulin as a Master Inhibitor of Cartilage-Degrading Factors That Attenuates the Progression of Posttraumatic Osteoarthritis.

Identification of a complex between fibronectin

(Clinical Biochemistry) Identification of a complex between fibronectin and aggrecan G3 domain in synovial fluid of patients with painful meniscal pathology.

Diagnostic Utility of Cytokine Biomarkers

By Jason M. Cuellar, MD, PhD, Gaetano J. Scuderi, MD, Vanessa Gabrovsky Cuellar, MD, S. Raymond Golish, MD, PhD, and David C. Yeomans, PhD

Read the research to learn more